| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80677-2mg买3赠1 |
99.90% | ￥149.00 |
2 | - | - | - | - |
|
S80677-5mg买3赠1 |
99.90% | ￥265.00 |
>10 | - | - | - | - |
|
S80677-10mg买3赠1 |
99.90% | ￥300.00 |
9 | - | - | - | - |
|
S80677-25mg买3赠1 |
99.90% | ￥380.00 |
2 | - | - | - | - |
|
S80677-50mg买3赠1 |
99.90% | ￥730.00 |
5 | - | - | - | - |
|
S80677-100mg买3赠1 |
99.90% | ￥1240.00 |
2 | - | - | - | - |
|
| 产品描述： | SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM. | ||||||||||||||||||||
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| 靶点： | IC50: 14.3 nM (ALK5);ALK;TGF-beta/Smad | ||||||||||||||||||||
| 体内研究： | SB525334 (3-30 mg/kg; p.o.; daily from days 17 to 35) significantly reverses pulmonary arterial pressure in a rat model of pulmonary arterial hypertension (PAH) | ||||||||||||||||||||
| 参考文献： | 1. Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther, 2005, 313(3), 943-951. 2. Thomas M, et al. ALK5 mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. 3. Laping NJ, et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res, 2007, 13(10), 3087-3899. | ||||||||||||||||||||
| 溶解性： | DMSO : 100 mg/mL (291.19 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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