货号	规格	价格	上海	北京	珠海	重庆	武汉
S80690-100mg买3赠1	99.80%	￥400.00 S80690-100mg ￥400.00 现货（买3赠1）	10 10	-	-	-	-
S80690-250mg买3赠1	99.80%	￥600.00 S80690-250mg ￥600.00 现货（买3赠1）	8 8	-	-	-	-
S80690-1g买3赠1	99.80%	￥1200.00 S80690-1g ￥1200.00 现货（买3赠1）	4 4	-	-	-	-

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产品描述：

Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

靶点：

HIV-1;HIV-2;HIVProtease;ReverseTranscriptase

体外研究：

Tenofovir alafenamide (GS-7340) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT

体内研究：

Tenofovir alafenamide (GS-7340) hemifumarate is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF)

参考文献：

1. Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66. 2. Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.099 ml	10.494 ml	20.988 ml
5 mM	0.42 ml	2.099 ml	4.198 ml
10 mM	0.21 ml	1.049 ml	2.099 ml
50 mM	0.042 ml	0.21 ml	0.42 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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