货号	规格	价格	上海	北京	珠海	重庆	武汉
S80697-1mg促销	≥98%	￥176.00 ￥140.00 S80697-1mg ￥140.00 现货	10 10	-	-	-	-
S80697-5mg促销	≥98%	￥454.00 ￥360.00 S80697-5mg ￥360.00 现货	10 10	-	-	-	-
S80697-25mg促销	≥98%	￥2220.00 ￥1770.00 S80697-25mg ￥1770.00 现货	1 1	-	-	-	-
S80697-100mg促销	≥98%	￥5560.00 ￥4440.00 S80697-100mg ￥4440.00 现货	2 2	-	-	-	-

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产品描述：

PHA-680632 is an aurora kinase inhibitor with IC50s of 27, 135 and 120 nM for aurora A, B and C, respectively.

靶点：

Aurora A:27 nM (IC50);Aurora B:135 nM (IC50);Aurora C:120 nM (IC50);FGFR;PLK;AuroraKinase

体内研究：

PHA-680632 suppresses tumor growth in animal models. PHA-680632 treatment at 45 mg/kg dose results in 85% of TGI without signs of toxicity in the HL60 human acute myelogenous leukemia xenograft model. PHA-680632 treatment at 60 mg/kg i.v. b.i.d. for 5 days results in 78% of TGI without signs of toxicity in the A2780 human ovarian carcinoma model. PHA680632 in association with radiation leads to an additive effect in cancer cells, especially in the p53-deficient cells, but does not act as a radiosensitiser

参考文献：

1. Soncini C, et al. PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity. Clin Cancer Res. 2006 Jul 1;12(13):4080-9. 2. Tao Y, et al. Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Br J Cancer. 2007 Dec 17;97(12):1664-72.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.993 ml	9.967 ml	19.935 ml
5 mM	0.399 ml	1.993 ml	3.987 ml
10 mM	0.199 ml	0.997 ml	1.993 ml
50 mM	0.04 ml	0.199 ml	0.399 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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