货号	规格	价格	上海	北京	武汉	南京	购买数量
S80699-10mg	98%	￥350.00 S80699-10mg ￥350.00 2-3天	0 货期：2-3天	-	-	-
S80699-50mg	98%	￥530.00 S80699-50mg ￥530.00 2-3天	0 货期：2-3天	-	-	-

产品介绍

Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.

产品描述：

Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.

靶点：

Wnt, β-catenin;Wnt/beta-catenin

体内研究：

Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression

参考文献：

1. Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66(5):885-91. 2. Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22. 3. Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.254 ml	21.27 ml	42.541 ml
5 mM	0.851 ml	4.254 ml	8.508 ml
10 mM	0.425 ml	2.127 ml	4.254 ml
50 mM	0.085 ml	0.425 ml	0.851 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Pamidronic Acid See P172500