货号	规格	价格	上海	北京	珠海	重庆	武汉
S80701-5mg买3赠1	99.40%	￥110.00 S80701-5mg ￥110.00 现货（买3赠1）	5 5	-	-	-	-
S80701-10mg买3赠1	99.40%	￥180.00 S80701-10mg ￥180.00 现货（买3赠1）	4 4	-	-	-	-
S80701-25mg买3赠1	99.40%	￥360.00 S80701-25mg ￥360.00 现货（买3赠1）	6 6	-	-	-	-
S80701-50mg买3赠1	99.40%	￥620.00 S80701-50mg ￥620.00 现货（买3赠1）	1 1	-	-	-	-
S80701-100mg买3赠1	99.40%	￥950.00 S80701-100mg ￥950.00 现货（买3赠1）	5 5	-	-	-	-

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产品描述：

Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation. Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5

靶点：

HSV-1;Dusp2;Apoptosis;Phosphatase;PERK;Autophagy;HSV

体内研究：

Salubrinal is a synthetic chemical that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Salubrinal significantly suppresses inflammation of the paws of CAIA mice. For instance, the clinical scores are 1.94±1.7 (placebo) and 0.31±0.6 (Salubrinal) on day 6; and 4.63±3.4 (placebo) and 1.09±1.6 (Salubrinal) on day 12. Consistent with the clinical scores, the thickening of the paws is also reduced in the Salubrinal-treated group. Furthermore, Salubrinal reduces the histological scores from 1.47±1.10 (N=16; placebo) to 0.59±0.64 (N=16; Salubrinal) (p=0.01)

参考文献：

1. Drexler HC. Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors. PLoS One. 2009;4(1):e4161. 2. Hamamura K, et al. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015 Apr;27(4):828-35. 3. Bryant KF, et al. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30;379(2):197-204.

溶解性：

DMSO : 50 mg/mL (104.21 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.084 ml	10.421 ml	20.842 ml
5 mM	0.417 ml	2.084 ml	4.168 ml
10 mM	0.208 ml	1.042 ml	2.084 ml
50 mM	0.042 ml	0.208 ml	0.417 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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