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CHIR-124,新型和Chk1抑制剂

    
≥99%

CHIR-124

源叶(MedMol)
S80703 一键复制产品信息
405168-58-3
C23H22ClN5O
419.91
(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one;CHIR-124
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S80703-1mg促销
≥99%

¥192.00 ¥172.00

10 - - - -
S80703-5mg促销
≥99%

¥580.00 ¥522.00

7 - - - -
S80703-25mg促销
≥99%

¥2000.00 ¥1800.00

6 - - - -
S80703-50mg促销
≥99%

¥3200.00 ¥2880.00

2 - - - -
S80703-100mg促销
≥99%

¥5200.00 ¥4680.00

2 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.
靶点: Chk1:0.3 nM (IC50);Chk2:697.4 nM (IC50);PDGFR:6.6 nM (IC50);FLT3:5.8 nM (IC50);Cdk4/cyclin D:2.05 μM (IC50);CDC2/cyclin B:0.5057 μM (IC50);Cdk2/cyclin A:0.1911 μM (IC50);bFGFR:2.01 μM (IC50);FGFR3:1.29 μM (IC50);VEGFR2 FLK1:0.5779 μM (IC50);VEGFR1 FLT1:0.4636 μM (IC50);PKCα:0.58 μM (IC50);PKAβ I:2.25 μM (IC50);PKCβ II:0.58 μM (IC50);PKCγ:0.11 μM (IC50);ERK2:4.31 μM (IC50);PKA:0.1031 μM (IC50);GSK3:0.0233 μM (IC50);Apoptosis;GSK-3;FLT;Chk;PDGFR;Src
体内研究: CHIR-124 (10 or 20 mg/kg, p.o.) does not have a significant effect on tumor growth when compared with the vehicle-treated group, but it potentiates the growth inhibitory effect of CPT-11 in a human breast carcinoma xenograft model. The potentiation of the tumor growth inhibitory effect of CPT-11 by CHIR-124 is associated with an increase in apoptosis induction in the tumors. CHIR-124 reverses the suppression of phospho-H3 staining induced by CPT-11, indicating abrogation of the G2-M checkpoint by CHIR-124
参考文献: 1. Tse AN, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13(2 Pt 1), 591-602. 2. Dai Y, et al. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res, 2010, 16(2), 376-383.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.381 ml 11.907 ml 23.815 ml
5 mM 0.476 ml 2.381 ml 4.763 ml
10 mM 0.238 ml 1.191 ml 2.381 ml
50 mM 0.048 ml 0.238 ml 0.476 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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