| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80703-1mg促销 |
≥99% | ￥192.00 ￥172.00 |
10 | - | - | - | - |
|
S80703-5mg促销 |
≥99% | ￥580.00 ￥522.00 |
7 | - | - | - | - |
|
S80703-25mg促销 |
≥99% | ￥2000.00 ￥1800.00 |
6 | - | - | - | - |
|
S80703-50mg促销 |
≥99% | ￥3200.00 ￥2880.00 |
2 | - | - | - | - |
|
S80703-100mg促销 |
≥99% | ￥5200.00 ￥4680.00 |
2 | - | - | - | - |
|
| 产品描述： | CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Chk1:0.3 nM (IC50);Chk2:697.4 nM (IC50);PDGFR:6.6 nM (IC50);FLT3:5.8 nM (IC50);Cdk4/cyclin D:2.05 μM (IC50);CDC2/cyclin B:0.5057 μM (IC50);Cdk2/cyclin A:0.1911 μM (IC50);bFGFR:2.01 μM (IC50);FGFR3:1.29 μM (IC50);VEGFR2 FLK1:0.5779 μM (IC50);VEGFR1 FLT1:0.4636 μM (IC50);PKCα:0.58 μM (IC50);PKAβ I:2.25 μM (IC50);PKCβ II:0.58 μM (IC50);PKCγ:0.11 μM (IC50);ERK2:4.31 μM (IC50);PKA:0.1031 μM (IC50);GSK3:0.0233 μM (IC50);Apoptosis;GSK-3;FLT;Chk;PDGFR;Src | ||||||||||||||||||||
| 体内研究： | CHIR-124 (10 or 20 mg/kg, p.o.) does not have a significant effect on tumor growth when compared with the vehicle-treated group, but it potentiates the growth inhibitory effect of CPT-11 in a human breast carcinoma xenograft model. The potentiation of the tumor growth inhibitory effect of CPT-11 by CHIR-124 is associated with an increase in apoptosis induction in the tumors. CHIR-124 reverses the suppression of phospho-H3 staining induced by CPT-11, indicating abrogation of the G2-M checkpoint by CHIR-124 | ||||||||||||||||||||
| 参考文献： | 1. Tse AN, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13(2 Pt 1), 591-602. 2. Dai Y, et al. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res, 2010, 16(2), 376-383. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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