货号	规格	价格	上海	北京	珠海	重庆	武汉
S80704-5mg买3赠1	99.85%	￥340.00 S80704-5mg ￥340.00 现货（买3赠1）	7 7	-	-	-	-
S80704-10mg买3赠1	99.85%	￥510.00 S80704-10mg ￥510.00 现货（买3赠1）	6 6	-	-	-	-
S80704-25mg买3赠1	99.85%	￥952.00 S80704-25mg ￥952.00 现货（买3赠1）	2 2	-	-	-	-
S80704-50mg买3赠1	≥99%	￥1490.00 S80704-50mg ￥1490.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S80704-100mg买3赠1	99.85%	￥2580.00 S80704-100mg ￥2580.00 现货（买3赠1）	7 7	-	-	-	-
S80704-200mg买3赠1	≥99%	￥4760.00 S80704-200mg ￥4760.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S80704-500mg	≥99%	￥7500.00 S80704-500mg ￥7500.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity

靶点：

FLT3:1 nM (IC50);c-Kit:2 nM (IC50);FGFR1:8 nM (IC50);FGFR3:9 nM (IC50);VEGFR3:8 nM (IC50);VEGFR1:10 nM (IC50);VEGFR2:13 nM (IC50);PDGFRβ:27 nM (IC50);PDGFRα:210 nM (IC50);CSF-1R:36 nM (IC50);VEGFR;FGFR;FLT;PDGFR;c-Kit

体内研究：

Dovitinib (CHIR-258; 10-60 mg/kg/day; gavage; for 21 days) has a significant antitumor effect. Dovitinib (50 and 75 mg/kg) results in 97% and 98% tumor growth inhibition, respectively, and the maximal efficacy is at 50 mg/kg.

参考文献：

1. Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005, 105(7), 2941-2948. 2. Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56(3), 595-601. 3. Lee Y, et al. A Receptor Tyrosine Kinase Inhibitor, Dovitinib (TKI-258), Enhances BMP-2-Induced Osteoblast Differentiation In Vitro. Mol Cells. 2016 May 31;39(5):389-94 4. Chon HJ, et al. Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells. Amino Acids. 2016 Jul;48(7):1591-9.

溶解性：

DMSO : 25 mg/mL (63.71 mM; Need ultrasonic and warming)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.548 ml	12.741 ml	25.482 ml
5 mM	0.51 ml	2.548 ml	5.096 ml
10 mM	0.255 ml	1.274 ml	2.548 ml
50 mM	0.051 ml	0.255 ml	0.51 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Dovitinib (TKI-258, CHIR-258)