源叶(MedMol)
S80704
一键复制产品信息
405169-16-6
C21H21FN6O
392.43
CHIR-258;多韦替尼;4-氨基-5-氟-3-[5-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基]喹啉-2(1H)-酮
Dovitinib (TKI-258, CHIR-258) 99.85%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80704-5mg |
99.85% | ￥340.00 |
7 | - | - | - | - |
|
S80704-10mg |
99.85% | ￥510.00 |
6 | - | - | - | - |
|
S80704-25mg |
99.85% | ￥952.00 |
2 | - | - | - | - |
|
S80704-50mg |
≥99% | ￥1490.00 |
货期：2-3天 | - | - | - | - |
|
S80704-100mg |
99.85% | ￥2580.00 |
7 | - | - | - | - |
|
S80704-200mg |
≥99% | ￥4760.00 |
货期：2-3天 | - | - | - | - |
|
S80704-500mg |
≥99% | ￥7500.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | FLT3:1 nM (IC50);c-Kit:2 nM (IC50);FGFR1:8 nM (IC50);FGFR3:9 nM (IC50);VEGFR3:8 nM (IC50);VEGFR1:10 nM (IC50);VEGFR2:13 nM (IC50);PDGFRβ:27 nM (IC50);PDGFRα:210 nM (IC50);CSF-1R:36 nM (IC50);VEGFR;FGFR;FLT;PDGFR;c-Kit | ||||||||||||||||||||
| 体内研究： | Dovitinib (CHIR-258; 10-60 mg/kg/day; gavage; for 21 days) has a significant antitumor effect. Dovitinib (50 and 75 mg/kg) results in 97% and 98% tumor growth inhibition, respectively, and the maximal efficacy is at 50 mg/kg. | ||||||||||||||||||||
| 参考文献： | 1. Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005, 105(7), 2941-2948. 2. Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56(3), 595-601. 3. Lee Y, et al. A Receptor Tyrosine Kinase Inhibitor, Dovitinib (TKI-258), Enhances BMP-2-Induced Osteoblast Differentiation In Vitro. Mol Cells. 2016 May 31;39(5):389-94 4. Chon HJ, et al. Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells. Amino Acids. 2016 Jul;48(7):1591-9. | ||||||||||||||||||||
| 溶解性： | DMSO : 25 mg/mL (63.71 mM; Need ultrasonic and warming) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献
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