| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80707-2mg买3赠1 |
98.10% | ￥224.00 |
9 | - | - | - | - |
|
S80707-5mg买3赠1 |
98.10% | ￥352.00 |
>10 | - | - | - | - |
|
S80707-10mg买3赠1 |
98.10% | ￥552.00 |
4 | 2 | 2 | - | - |
|
S80707-25mg买3赠1 |
98.10% | ￥960.00 |
6 | 2 | - | - | - |
|
S80707-100mg买3赠1 |
98.10% | ￥2080.00 |
6 | 2 | - | - | - |
|
| 产品描述： | Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | ySir2:48 μM (IC50);hSIRT2:57.7 μM (IC50);hSIRT1:131 μM (IC50);Apoptosis;Sirtuin;Autophagy | ||||||||||||||||||||
| 体内研究： | Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury | ||||||||||||||||||||
| 参考文献： | 1. Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109. 2. Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. 3. Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95. 4. Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. | ||||||||||||||||||||
| 溶解性： | DMSO : 10 mg/mL (25.35 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京