货号	规格	价格	上海	北京	珠海	重庆	武汉
S80713-2mg买3赠1	99.80%	￥90.00 S80713-2mg ￥90.00 现货（买3赠1）	3 3	-	-	-	-
S80713-5mg	99.80%	￥120.00 S80713-5mg ￥120.00 现货	5 5	-	-	-	-
S80713-10mg	99.80%	￥220.00 S80713-10mg ￥220.00 现货	3 3	-	-	-	-
S80713-25mg	99.80%	￥440.00 S80713-25mg ￥440.00 现货	6 6	-	-	-	-
S80713-50mg	≥99%	￥750.00 S80713-50mg ￥750.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively

靶点：

PKCθ:0.22 nM (Ki);PKCβI:0.64 nM (Ki);PKCα:0.95 nM (Ki);PKCη:1.8 nM (Ki);PKCδ:2.1 nM (Ki);PKCε:3.2 nM (Ki);PKC

体内研究：

The combination therapy results in a significantly enhanced reduction in tumor volume when compared to either Sotrastaurin (AEB071) or BYL719 alone (p=0.049 vs. BYL719 and p=0.022 vs. Sotrastaurin at day 26). There is even a greater effect when compared to vehicle control (p=0.016). Sotrastaurin (STN) treatment of liver donors and orthotopic liver transplantation (OLT) recipients (Gr.I) or of OLT recipients alone (Gr.II) prolongs animal survival, as 9 out of 10 rats in Gr. I, and 6 out of 6 rats in Gr.II survive >14 days. In contrast, only 4 out of 10 control OLT recipients remain alive at day 14 (p<0.01)

参考文献：

1. Evenou JP, et al. The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. 2. Musi E, et al. The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells. Mol Cancer Ther. 2014 May;13(5):1044-53 3. Kamo N, et al. Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11(11):2499-507.

溶解性：

DMSO : ≥ 50 mg/mL (114.03 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.281 ml	11.403 ml	22.806 ml
5 mM	0.456 ml	2.281 ml	4.561 ml
10 mM	0.228 ml	1.14 ml	2.281 ml
50 mM	0.046 ml	0.228 ml	0.456 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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