货号	规格	价格	上海	北京	珠海	重庆	武汉
S80716-5mg买3赠1	99.30%	￥180.00 S80716-5mg ￥180.00 现货（买3赠1）	11 >10	-	-	-	-
S80716-10mg买3赠1	99.30%	￥245.00 S80716-10mg ￥245.00 现货（买3赠1）	1 4 1	2	2	-	-
S80716-25mg买3赠1	99.30%	￥480.00 S80716-25mg ￥480.00 现货（买3赠1）	6 6	-	-	-	-
S80716-50mg买3赠1	≥99%	￥750.00 S80716-50mg ￥750.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S80716-100mg买3赠1	99.30%	￥1100.00 S80716-100mg ￥1100.00 现货（买3赠1）	1 1	-	-	-	-
S80716-200mg买3赠1	99.30%	￥1950.00 S80716-200mg ￥1950.00 现货（买3赠1）	3 3	-	-	-	-

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产品描述：

Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor

靶点：

EC50: 182 nM (RIP1 kinase);Indoleamine2,3-Dioxygenase(IDO);Ferroptosis;Autophagy;RIPkinase

体内研究：

Necrostatin-1 (Nec-1) induces tubular bilation and affects the kinetics of the dilation of peritubular capillaries after RCM application. Upon a single intraperitoneal application of a single dose of Necrostatin-1 (1.65 mg/kg body weight, i.p.) 15 minutes before RCM, the return to baseline levels is prevented within the observation period

参考文献：

1. Degterev A, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1(2):112-9. 2. Linkermann A, et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol. 2013 Oct;24(10):1545-57. 3. Huang C, et al. Shikonin kills glioma cells through necroptosis mediated by RIP-1. PLoS One. 2013 Jun 28;8(6):e66326. 4. Feyen D, et al. Increasing short-term cardiomyocyte progenitor cell (CMPC) survival by necrostatin-1 did not further preserve cardiac function. Cardiovasc Res. 2013 Jul 1;99(1):83-91. 5. Zhou K, et al. RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Exp Neurol. 2017 Sep;295:116-124.

溶解性：

DMSO : ≥ 46 mg/mL (177.38 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.856 ml	19.28 ml	38.561 ml
5 mM	0.771 ml	3.856 ml	7.712 ml
10 mM	0.386 ml	1.928 ml	3.856 ml
50 mM	0.077 ml	0.386 ml	0.771 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(6篇)

6. [IF=4.1] Yongchang Lai et al."Dioscin initiates dual roles in bladder cancer progression via miR-195–5p/FASN/SLC3A2 axis-mediated cell death mechanisms."Translational Oncology.2025 Nov;61:102534 5. [IF=5.4] Lin-Song Teng et al."Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury."CHEMICO-BIOLOGICAL INTERACTIONS.2025 Nov;421:111724 4. [IF=8.2] Xin Hu et al."Poly(sodium lipoate) Particles with Nitroimidazole Modification for Disulfide Stress-Mediated Antitumor Metastasis."ACS Applied Materials & Interfaces.2025;XXXX(XXX):XXX-XXX 3. [IF=2.5] Zhong He et al."4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis."FITOTERAPIA.2025 Apr;:106567 2. [IF=4.6] Jiazhen Huang et al."BBOX1 mediates metabolic reprogramming driven by hypoxia and participates in the malignant progress of high-grade serous ovarian cancer."BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH.2024 Aug;:119830

1. [IF=10.5] Mengqi Jia et al."An injectable biomimetic hydrogel adapting brain tissue mechanical strength for postoperative treatment of glioblastoma without anti-tumor drugs participation."JOURNAL OF CONTROLLED RELEASE.2024 Sep;373:699

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