| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80717-2mg买3赠1 |
99.40% | ￥140.00 |
9 | - | - | - | - |
|
S80717-5mg买3赠1 |
99.40% | ￥212.00 |
9 | - | - | - | - |
|
S80717-10mg促销 |
99.40% | ￥355.00 ￥284.00 |
7 | - | - | - | - |
|
S80717-25mg促销 |
99.40% | ￥710.00 ￥568.00 |
6 | - | - | - | - |
|
S80717-50mg促销 |
99.40% | ￥1210.00 ￥968.00 |
4 | - | - | - | - |
|
S80717-100mg促销 |
≥99% | ￥2050.00 ￥1640.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM. | ||||||||||||||||||||
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| 靶点： | IKK:88 nM (IC50);Apoptosis;IκB/IKK | ||||||||||||||||||||
| 体内研究： | Administration of either Bortezomib or PS-1145 (50 mg/kg) results in a significant decrease in serum levels of all 3 cytokines that is nonsignificantly different from those in mice that underwent transplantation with TCD BM alone. PS1145 is injected intracerebroventricular (icv) as a pretreatment to block hypothalamic inflammation induced by IL-4 in adult male Wistar rats consuming a high-fat diet (HFD) over an 11-day period. The four groups of rats according to icv pretreatment/treatment condition are Veh/Veh, Veh/IL-4, PS1145/Veh, and PS1145/IL-4. Rats in the Veh/IL-4 group display increased weight gain on the HFD compared with the Veh/Veh group (P<0.05 on days 6-9). Importantly, the effect of icv IL-4 administration to increase body fat mass during high-fat (HF) feeding is completely blocked by icv PS1145 pretreatment at a dose that has no independent effect on body composition (on day 8: P<0.001, PS1145/Veh vs. PS1145/IL-4; P=not significant, PS1145/Veh vs. Veh/Veh). In PS1145/IL-4 injected rats, IL-1β mRNA content is decreased by ~75% compared with that of Veh/IL-4-injected rats | ||||||||||||||||||||
| 参考文献： | 1. Hideshima T, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10;277(19):16639-47. 2. Vodanovic-Jankovic S, et al. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood. 2006 Jan 15;107(2):827-34. 3. Oh-I S, et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E47-53. | ||||||||||||||||||||
| 溶解性： | DMSO : 20.83 mg/mL (64.54 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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