BMS-345541

99.90%

BMS-345541 free base

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品牌：源叶(MedMol)

产品编号：S80724 一键复制产品信息

CAS号：445430-58-0

分子式：C₁₄H₁₇N₅

分子量：255.32

别名：BMS-345541 free base; BMS345541; UNII-26SU0NEF5F; BMS 345541; BMS-345541

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80724-5mg买3赠1	99.90%	￥612.00 S80724-5mg ￥612.00 现货（买3赠1）	3 3	-	-	-	-
S80724-10mg买3赠1	99.90%	￥952.00 S80724-10mg ￥952.00 现货（买3赠1）	7 7	-	-	-	-
S80724-25mg买3赠1	99.90%	￥1900.00 S80724-25mg ￥1900.00 现货（买3赠1）	8 8	-	-	-	-
S80724-100mg买3赠1	99.90%	￥4280.00 S80724-100mg ￥4280.00 现货（买3赠1）	2 0 2	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

BMS-345541 is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.

靶点：

IKK-2:0.3 μM (IC50);IKK-1:4 μM (IC50);IκB/IKK

体内研究：

BMS-345541 (10 mg/kg, p.o.) results in prolonged serum drug levels, with concentrations sustained at or above 1 μM for many hours in mice. BMS-345541 dose-dependently inhibits the production of TNFα measured in the serum of animals challenged with an intraperitoneal administration of LPS. BMS-345541 (0, 10, 25, and 75 mg/kg, p.o.) effectively inhibits SK-MEL-5 tumor growth in a dose-dependent manner in the mice. Tumor-bearing mice treated with 75 mg/kg of BMS-345541 show effective inhibition of growth of SK-MEL-5, A375, and Hs 294T tumors by 86±2.8%, 69±11% and 67±3.4%, respectively

参考文献：

1. Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456. 2. Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960. 3. MacMaster JF, et al. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res, 2003, 52(12), 508-511.

溶解性：

DMSO : 10 mg/mL (39.17 mM; Need ultrasonic) H2O : 10 mg/mL (39.17 mM; ultrasonic and warming and heat to 60°C)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.917 ml	19.583 ml	39.167 ml
5 mM	0.783 ml	3.917 ml	7.833 ml
10 mM	0.392 ml	1.958 ml	3.917 ml
50 mM	0.078 ml	0.392 ml	0.783 ml