货号	规格	价格	上海	北京	珠海	重庆	武汉
S80737-1mg促销	≥98%	￥350.00 ￥150.00 S80737-1mg ￥150.00 现货	10 10	-	-	-	-
S80737-5mg促销	≥98%	￥1290.00 ￥550.00 S80737-5mg ￥550.00 现货	10 10	-	-	-	-
S80737-25mg促销	≥98%	￥5150.00 ￥1350.00 S80737-25mg ￥1350.00 现货	4 4	-	-	-	-
S80737-50mg促销	≥98%	￥6480.00 ￥2150.00 S80737-50mg ￥2150.00 现货	1 1	-	-	-	-

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产品描述：

NVP-AEW541 (AEW541) is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM

靶点：

IC50: 0.15 ±0.036 μM (IGF-IR), 0.14±0.039 μM (InsR), 0.42±0.11 μM (Flt-3), 2±0.61 μM (PDGFR), 2.4±0.38 μM (c-Src), 3.3±1.4 μM (c-Kit);FLT;TyrosineKinases;IGF-1R;Autophagy

体内研究：

Oral administration of NVP-AEW541 (20, 30, or 50 mg/kg) results in abrogation of basal and IGF-I-induced receptor, and PKB and MAPK phosphorylation in the NWT-21 tumor xenograft. NVP-AEW541 is administered by oral gavage [50 mg/kg in 0.2 mL of 25 mM L-(+)-tartaric acid] twice a day for 14 consecutive days. The control group is similarly treated with 0.2 mL carrier [25 mM L-(+)-tartaric acid] twice a day. Tumor volume and animal weight are measured thrice a week till the end of the treatment. At that time, animals are sacrificed and tumors are collected and formalin fixed for histologic and immunohistochemical analyses. In both cases, NVP-AEW541 treatment causes tumor shrinkage that reached the statistical significance (P=0.0156 and P=0.0111 for HTLA-230 and SK-N-BE2c, respectively)

参考文献：

1. García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9. 2. Tanno B, et al. Down-regulation of IGF-1 receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006, 12(22), 6772-6780.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.275 ml	11.375 ml	22.751 ml
5 mM	0.455 ml	2.275 ml	4.55 ml
10 mM	0.228 ml	1.138 ml	2.275 ml
50 mM	0.046 ml	0.228 ml	0.455 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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