| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80738-2mg买3赠1 |
96.50% | ￥280.00 |
5 | - | - | - | - |
|
S80738-5mg买3赠1 |
96.50% | ￥420.00 |
6 | - | - | - | - |
|
S80738-10mg买3赠1 |
96.50% | ￥690.00 |
3 | - | - | - | - |
|
S80738-25mg买3赠1 |
96.50% | ￥1460.00 |
5 | - | - | - | - |
|
S80738-50mg |
≥96% | ￥2400.00 |
货期：2-3天 | - | - | - | - |
|
S80738-100mg |
≥96% | ￥3900.00 |
货期：2-3天 | - | - | - | - |
|
S80738-200mg |
≥96% | ￥7000.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM; IC50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Ki: 4 nM IC50: 9 nM (c-Met);Apoptosis;VEGFR;FGFR;c-Met/HGFR;Bcr-Abl;Autophagy | ||||||||||||||||||||
| 体内研究： | PHA-665752 (7.5-30 mg/kg/day; i.v. ; for 9 days) exhibits statistically significant dose-dependent tumor growth inhibition of 68%, 39%, and 20% of vehicle control at the 30 mg/kg/day, 15 mg/kg/day, and 7.5 mg/kg/day doses, respectively. PHA-665752 shows a potent cytoreductive activity in a gastric carcinoma xenograft model. | ||||||||||||||||||||
| 参考文献： | 1. Christensen JG, et al. A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res. 2003 Nov 1;63(21):7345-55. 2. Ma PC. et al. A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin. Clin Cancer Res. 2005 Mar 15;11(6):2312-9. | ||||||||||||||||||||
| 溶解性： | DMSO : 25 mg/mL (38.96 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京