| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80748-5mg |
99.0% | ￥90.00 | 3 | - | - | - |
|
S80748-10mg |
99.0% | ￥136.00 | 6 | - | - | - |
|
S80748-1mg |
99.0% | ￥197.00 | 9 | - | - | - |
|
S80748-25mg |
99.0% | ￥226.00 | 8 | - | - | - |
|
S80748-50mg |
99.0% | ￥425.00 | 5 | - | - | - |
|
S80748-100mg |
99.0% | ￥750.00 | 2 | - | - | - |
|
GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
| 产品描述： | GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Gli1/2;Hedgehog/Smoothened;Autophagy | ||||||||||||||||||||
| 体内研究： | GANT-61 (40 mg/kg, i.p., three days per week) inhibits CSC tumor growth in NOD/SCID IL2Rγ null mice. GANT61 (50 mg/kg, p.o.) enhances the effects of chemotherapeutic drugs used in the treatment of neuroblastoma in an additive or synergistic manner and reduces the growth of established neuroblastoma xenografts in nude mice | ||||||||||||||||||||
| 参考文献： | 1. Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71(3):1092-102. 2. Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330(1):22-32. 3. Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132(7):1516-24. | ||||||||||||||||||||
| 溶解性： | Ethanol : 66.67 mg/mL (155.19 mM; Need ultrasonic) DMSO : 25 mg/mL (58.19 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京