| 产品描述： | Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning |
| 靶点： |
Cholinesterase (ChE) |
| 体内研究： |
Pralidoxime chloride (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice |
| 参考文献： |
1. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. 2. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. 3. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138. |
| 溶解性： |
H2O : ≥ 100 mg/mL (579.34 mM) DMSO : 21.67 mg/mL (125.54 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
5.793 ml |
28.967 ml |
57.934 ml |
| 5 mM |
1.159 ml |
5.793 ml |
11.587 ml |
| 10 mM |
0.579 ml |
2.897 ml |
5.793 ml |
| 50 mM |
0.116 ml |
0.579 ml |
1.159 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京