| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
| S80774-1mg | 98% | ￥264.00 | 7 | - | - | - |
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| S80774-2mg | 98% | ￥472.00 | 8 | - | - | - |
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| S80774-5mg | 98% | ￥624.00 | 9 | - | - | - |
|
| S80774-10mg | 98% | ￥1040.00 | 7 | - | - | - |
|
| S80774-25mg | 98% | ￥1700.00 | 10 | - | - | - |
|
| S80774-50mg | 98% | ￥2200.00 | 10 | - | - | - |
|
(E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1
| 产品描述： | (E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 | ||||||||||||||||||||
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| 靶点： | IC50: 3 μM (Smad3 phosphorylation);TGF-beta/Smad | ||||||||||||||||||||
| 参考文献： | 1. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607. 2. Zhu X, et al. Sphingosine kinase 2 cooperating with Fyn promotes kidney fibroblast activation and fibrosis via STAT3 and AKT. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3824-3836. 3. Liu J, et al. Topical TWEAK Accelerates Healing of Experimental Burn Wounds in Mice. Front Pharmacol. 2018 Jun 21;9:660. 4. Li FF, et al. Identification and characterization of an R-Smad homologue (Hco-DAF-8) from Haemonchuscontortus. Parasit Vectors. 2020 Apr 3;13(1):164. | ||||||||||||||||||||
| 溶解性： | DMSO : 125 mg/mL (255.11 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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