货号	规格	价格	上海	北京	珠海	重庆	武汉
S80792-5mg	99.80%	￥425.00 S80792-5mg ￥425.00 现货	3 3	-	-	-	-
S80792-10mg	99.80%	￥680.00 S80792-10mg ￥680.00 现货	1 1	-	-	-	-
S80792-25mg	≥99%	￥1360.00 S80792-25mg ￥1360.00 2-3天	0 货期：2-3天	-	-	-	-
S80792-100mg促销	≥99%	￥4080.00 ￥4000.00 S80792-100mg ￥4000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.

靶点：

NF-κB:11 nM (IC50, in human Jurkat cells transfected with pNFκB-Luc);TNF;NF-κB

参考文献：

1. Tobe M, et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation. 2. Nekrasov ED, et al. Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. Mol Neurodegener. 2016 Apr 14;11:27. 3. Wu J, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016 Jan 6;36(1):125-41.

溶解性：

DMSO : ≥ 37 mg/mL (103.81 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.806 ml	14.028 ml	28.057 ml
5 mM	0.561 ml	2.806 ml	5.611 ml
10 mM	0.281 ml	1.403 ml	2.806 ml
50 mM	0.056 ml	0.281 ml	0.561 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(2篇)

2. [IF=6.986] Tang Guanxiu et al."Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway."INFLAMMATION RESEARCH.2022 Jul;:1-12 1. Zhang, Zhi Hong, et al. "Chelidonine inhibits TNF‐α‐induced inflammation by suppressing the NF‐κB pathways in HCT116 cells." Phytotherapy Research 32.1 (2018): 65-75.https://doi.org/10.1002/ptr.5948

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