| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80816-5mg买3赠1 |
99.80% | ￥140.00 |
4 | - | - | - | - |
|
S80816-10mg买3赠1 |
99.80% | ￥210.00 |
2 | - | - | - | - |
|
S80816-25mg |
99.80% | ￥380.00 |
4 | - | - | - | - |
|
S80816-100mg |
99.80% | ￥1240.00 |
2 | - | - | - | - |
|
| 产品描述： | KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. | ||||||||||||||||||||
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| 靶点： | ATM:12.9 nM (IC50);DNA-PK:2500 nM (IC50);mTOR:9300 nM (IC50);PI3K:16600 nM (IC50) | ||||||||||||||||||||
| 参考文献： | 1. Hickson I, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64(24):9152-9 2. Khalil HS, et al. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.Exp Biol Med (Maywood). 2012 Jun;237(6):622-34. Epub 2012 Jun 22. 3. Kim YD, et al. Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.J Biol Chem. 2012 Sep 12. | ||||||||||||||||||||
| 溶解性： | DMSO : 80 mg/mL (202.28 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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