| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80833-1mg促销 |
≥97% | ￥64.00 ￥56.00 |
10 | 3 | 2 | - | - |
|
S80833-5mg促销 |
≥97% | ￥126.00 ￥114.00 |
10 | 2 | - | - | - |
|
S80833-25mg促销 |
≥97% | ￥430.00 ￥386.00 |
10 | 3 | 2 | - | - |
|
S80833-100mg促销 |
≥97% | ￥1220.00 ￥1100.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | SB742457 (GSK 742457)是一种高选择性5-HT6受体拮抗剂，pKi为9.63，比作用于其他受体选择性高100倍以上。Phase 2 | ||||||||||||||||||||
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| 靶点： | 5-HT6:9.63(pKi);5-HTReceptor | ||||||||||||||||||||
| 体外研究： | Intepirdine (SB742457), a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. Intepirdine (SB742457) is generally safe and well tolerated and may be efficacious in Alzheimer disease. | ||||||||||||||||||||
| 体内研究： | SB-742457是一种有效的，选择性5-HT6受体拮抗剂，在新物体识别测试中，可逆转Scopolamine诱导的学习缺陷，在老年大鼠水迷宫任务中，可提高学习性能 | ||||||||||||||||||||
| 参考文献： | 1. Chuang ATT, et al. Alzheimers Dement, 2006, 2, S631–S632 (abstract). 2. Upton N, et al. Neurotherapeutics, 2008, 5(3), 458-469. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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