货号	规格	价格	上海	北京	珠海	重庆	武汉
S80837-5mg促销	≥98%(HPLC)	￥600.00 ￥315.00 S80837-5mg ￥315.00 现货	1 1	-	-	-	-
S80837-10mg促销	≥98%(HPLC)	￥1000.00 ￥600.00 S80837-10mg ￥600.00 2-3天	0 货期：2-3天	-	-	-	-
S80837-50mg促销	≥98%(HPLC)	￥3200.00 ￥2200.00 S80837-50mg ￥2200.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

AKT inhibitor VIII (AKTi-1/2) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2119 nM, respectively.

靶点：

Akt1:58 nM (IC50);Akt2:210 nM (IC50);Akt3:2119 nM (IC50);Apoptosis;Akt

体内研究：

Mice are dosed with AKT inhibitor VIII (50 mpk, 3 doses, ip, every 90 min) achieving plasma concentrations of 1.5-2.0 μM, and then the animals are tail vein injected with IGF to stimulate Akt phosphorylation. By IP Western, both basal and IGF stimulated Akt1 and Akt2 phosphorylation are inhibited in mouse lung, with no effect on Akt3 phosphorylation

参考文献：

1. Lindsley, et al. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg. Med. Chem. Lett. (2005), 15(3), 761-764. 2. Zhong Z, et al. Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo. Cell Physiol Biochem. 2012;30(3):778-90. Epub 2012 Aug 2. 3. Leonardo Romorini, et al. AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival. Sci Rep. 2016; 6: 35660

溶解性：

DMSO : 20 mg/mL (36.26 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.813 ml	9.064 ml	18.128 ml
5 mM	0.363 ml	1.813 ml	3.626 ml
10 mM	0.181 ml	0.906 ml	1.813 ml
50 mM	0.036 ml	0.181 ml	0.363 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Akti-1/2