货号	规格	价格	上海	北京	珠海	重庆	武汉
S80843-1mg	≥98%	￥270.00 S80843-1mg ￥270.00 现货	10 10	-	-	-	-
S80843-5mg	≥98%	￥940.00 S80843-5mg ￥940.00 现货	6 6	-	-	-	-
S80843-25mg	≥98%	￥2700.00 S80843-25mg ￥2700.00 现货	2 2	-	-	-	-

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产品描述：

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. IC50 value: Target: Antibiotic agent AFN-1252 was inactive (MIC90, >4 μg/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections

靶点：

Bacterial;Antibiotic;Antibacterial;Antibiotic

体内研究：

AFN-1252 (0.03-3 mg/kg；口服灌胃；单剂量) 对败血症小鼠模型有效，单次口服剂量 1 mg/kg 可获得 100% 存活率。

参考文献：

1. Karlowsky JA, et al. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8. 2. Narasimha Rao K, et al. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei-Crystal structure, mode of action, and biological activity. Protein Sci. 2015 May;24(5):832-40. 3. Yao J, et al. Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71. 4. Parsons JB, et al. Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother. 2013 May;57(5):2182-90.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.664 ml	13.318 ml	26.637 ml
5 mM	0.533 ml	2.664 ml	5.327 ml
10 mM	0.266 ml	1.332 ml	2.664 ml
50 mM	0.053 ml	0.266 ml	0.533 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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