Oltipraz

99.60%

Oltipraz

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品牌：源叶(MedMol)

产品编号：S80861 一键复制产品信息

CAS号：64224-21-1

分子式：C₈H₆N₂S₃

分子量：226.34

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80861-5mg	99.60%	￥230.00 S80861-5mg ￥230.00 现货	1805 >10	-	-	-	-
S80861-10mg	99.60%	￥340.00 S80861-10mg ￥340.00 现货	907 >10	-	-	-	-
S80861-50mg	99.60%	￥670.00 S80861-50mg ￥670.00 现货	186 >10	-	-	-	-
S80861-100mg	99.60%	￥1020.00 S80861-100mg ￥1020.00 现货	96 0 >10	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

靶点：

IC50: 10 μM (HIF-1α) Nrf2;HIF/HIFProlyl-Hydroxylase;HIVProtease;ReverseTranscriptase;Nrf2;HIF

体内研究：

In wild-type mice, hepatic levels of mRNA for all of the genes analyzed were significantly increased after Oltipraz treatment, with the highest increase (treated/control) for NQO1 mRNA levels (7.6-fold). The Northern blot analyses demonstrated that the observed increases in GST and NQO1 activities by Oltipraz in wild-type mice were preceded by significant elevations in RNA expression. Interestingly, mRNA levels of Nrf2 itself were increased more than 3-fold by Oltipraz treatment.

参考文献：

1. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802. 2. Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87. 3. Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5. 4. Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49(2):324-33.

溶解性：

DMSO : 6 mg/mL (26.51 mM; Need ultrasonic and warming)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.418 ml	22.091 ml	44.181 ml
5 mM	0.884 ml	4.418 ml	8.836 ml
10 mM	0.442 ml	2.209 ml	4.418 ml
50 mM	0.088 ml	0.442 ml	0.884 ml