货号	规格	价格	上海	北京	珠海	重庆	武汉
S80867-5mg买3赠1	99.50%	￥120.00 S80867-5mg ￥120.00 现货（买3赠1）	6 6	-	-	-	-
S80867-10mg买3赠1	99.50%	￥178.00 S80867-10mg ￥178.00 现货（买3赠1）	7 7	-	-	-	-
S80867-50mg促销	99.50%	￥350.00 ￥280.00 S80867-50mg ￥280.00 现货	5 5	-	-	-	-
S80867-25mg买3赠1	99.50%	￥280.00 S80867-25mg ￥280.00 现货（买3赠1）	6 6	-	-	-	-
S80867-100mg促销	99.50%	￥590.00 ￥472.00 S80867-100mg ￥472.00 现货	5 5	-	-	-	-
S80867-200mg促销	≥98%	￥990.00 ￥792.00 S80867-200mg ￥792.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.

靶点：

Bcl-2:9 μM (IC50);Bcl-xL;BCL

体内研究：

Swiss nude mice are challenged with BeGBM cells (104 injected s.c.). HA14-1 (400 nmol) in 100 μL free RPMI 1640-50% DMSO, or the carrier alone, is given at the site of injection once weekly from day 2 following cell injection. HA14-1 treatment does not have any significant effect on the growth of glioblastoma tumors in immunodeficient mice as monitored twice weekly by measuring the volume of the expanding tumors. Moreover, no gross organ toxicity or weight loss can be detected in mice receiving such treatment. To analyze whether HA14-1 treatment might enhance the efficiency of another antitumoral treatment, Swiss nude mice challenged with human glioblastoma multiforme cells are also given i.p. low doses of Etoposide (2.5 mg/kg in 200 μL of 0.9% NaCl 5 days a week from day 2 following cell injection) together with HA14-1 or mock treatment. Whereas Etoposide treatment is insufficient by itself to restrain the growth of glioblastoma cells, its combination with HA14-1 leads to a significant restrain on tumor growth as judged by the ability of the combined treatment to increase the doubling time of the tumor volume

参考文献：

1. Wang JL, et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7124-9. 2. Kessel D, et al. Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1. Cancer Lett. 2007 May 8;249(2):294-9. 3. Manero F, et al. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res. 2006 Mar 1;66(5):2757-64.

溶解性：

DMSO : ≥ 50 mg/mL (122.18 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.444 ml	12.218 ml	24.436 ml
5 mM	0.489 ml	2.444 ml	4.887 ml
10 mM	0.244 ml	1.222 ml	2.444 ml
50 mM	0.049 ml	0.244 ml	0.489 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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