| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80870-1mg |
99.0% | ￥232.00 | 8 | - | - | - |
|
S80870-5mg |
≥99% | ￥432.00 | 货期：2-3天 | - | - | - |
|
S80870-10mg |
99.0% | ￥800.00 | 8 | - | - | - |
|
S80870-25mg |
≥99% | ￥1520.00 | 货期：2-3天 | - | - | - |
|
S80870-50mg |
99.0% | ￥2560.00 | 2 | - | - | - |
|
S80870-100mg |
≥99% | ￥4400.00 | 货期：2-3天 | - | - | - |
|
(E)-Daporinad (FK866) is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with an IC50 of 0.09 nM.
| 产品描述： | (E)-Daporinad (FK866) is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with an IC50 of 0.09 nM. | ||||||||||||||||||||
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| 靶点： | IC50: 0.09 nM (NMPRTase) | ||||||||||||||||||||
| 体内研究： | (E)-Daporinad (FK866) (30 mg/kg, i.p.) decreases the tumor burden in CB17-SCID mice, and the tumor tissue demonstrates a significant decrease in ERK phosphorylation and proteolytic cleavage of LC3 | ||||||||||||||||||||
| 参考文献： | 1. Cea M, et al. Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood. 2012 Oct 25;120(17):3519-29. 2. Magnone M, et al. NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes. J Biol Chem. 2012 Jun 15;287(25):21067-81. 3. Thakur BK, et al. Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. Biochem Biophys Res Commun. 2012 Aug 3;424(3):371-7. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 50 mg/mL (127.71 mM) H2O : 1 mg/mL (2.55 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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