| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80880-2mg买3赠1 |
98.05% | ￥229.00 |
4 | - | - | - | - |
|
S80880-5mg买3赠1 |
98.05% | ￥340.00 |
6 | - | - | - | - |
|
S80880-10mg买3赠1 |
98.05% | ￥510.00 |
6 | - | - | - | - |
|
S80880-25mg买3赠1 |
98.05% | ￥935.00 |
6 | - | - | - | - |
|
S80880-50mg促销 |
≥98% | ￥1360.00 ￥1080.00 |
货期：2-3天 | - | - | - | - |
|
S80880-100mg促销 |
≥98% | ￥2120.00 ￥1690.00 |
货期：2-3天 | - | - | - | - |
|
S80880-200mg促销 |
≥98% | ￥4080.00 ￥3260.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC50 of 25 μM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 0.88 μM (UCH-L1), 25 μM (UCH-L3) Ki: 0.40 μM (UCH-L1);Apoptosis;DUB | ||||||||||||||||||||
| 体内研究： | LDN-57444 (0.4 mg/kg, i.p.) blocks the beneficial effect of V-Uch-L1, and worsens contextual conditioning performance as the mice are exposed to the context at 1, 7, 14, and 21 days after training | ||||||||||||||||||||
| 参考文献： | 1. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep;10(9):837-46. 2. Gong B, et al. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell. 2006 Aug 25;126(4):775-88. 3. Tan YY, et al. Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol Cell Biochem. 2008 Nov;318(1-2):109-15. | ||||||||||||||||||||
| 溶解性： | DMSO : 25 mg/mL (62.87 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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