货号	规格	价格	上海	北京	珠海	重庆	武汉
S80886-1mg促销	≥98%	￥160.00 ￥144.00 S80886-1mg ￥144.00 现货	8 8	-	-	-	-
S80886-5mg促销	≥98%	￥400.00 ￥360.00 S80886-5mg ￥360.00 现货	6 6	-	-	-	-
S80886-10mg促销	≥98%	￥600.00 ￥540.00 S80886-10mg ￥540.00 现货	4 4	-	-	-	-
S80886-25mg促销	≥98%	￥1000.00 ￥900.00 S80886-25mg ￥900.00 现货	4 4	-	-	-	-
S80886-50mg促销	≥98%	￥1500.00 ￥1350.00 S80886-50mg ￥1350.00 现货	3 3	-	-	-	-

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产品描述：

Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

靶点：

IC50: 4 nM (dopamine), 6 nM (norepinephrine), 11 nM (serotonin);DopamineReceptor;5-HTReceptor;SerotoninTransporter;Norepinephrine

体内研究：

Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg

参考文献：

1. Guiard BP, et al. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. Int J Neuropsychopharmacol. 2011 Mar;14(2):211-23. 2. DeLorenzo C, et al. SEP-225289 serotonin and dopamine transporter occupancy: a PET study.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.043 ml	15.213 ml	30.427 ml
5 mM	0.609 ml	3.043 ml	6.085 ml
10 mM	0.304 ml	1.521 ml	3.043 ml
50 mM	0.061 ml	0.304 ml	0.609 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

(1R, 4S)-N-去甲基舍曲林盐酸盐

(1R,4S)-N-Desmethyl Sertraline Hydrochloride

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)