| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80900-2mg买3赠1 |
99.90% | ￥240.00 |
5 | - | - | - | - |
|
S80900-5mg买3赠1 |
99.90% | ￥300.00 |
7 | - | - | - | - |
|
S80900-10mg买3赠1 |
99.90% | ￥490.00 |
6 | - | - | - | - |
|
S80900-25mg买3赠1 |
99.90% | ￥1040.00 |
6 | - | - | - | - |
|
S80900-50mg买3赠1 |
99.90% | ￥1730.00 |
5 | - | - | - | - |
|
S80900-100mg买3赠1 |
99.90% | ￥2770.00 |
5 | - | - | - | - |
|
| 产品描述： | CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively. | ||||||||||||||||||||
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| 靶点： | Aurora A:8 nM (Ki);Aurora B:9.2 nM (Ki) | ||||||||||||||||||||
| 体内研究： | Oral administration of CYC-116 at dose levels of 75 and 100 mg/kg q.d. causes tumor growth delays of 2.3 and 5.8 days, which translates into specific growth delays of 0.32 and 0.81, respectively. The mean relative tumor volumes of mice receiving CYC-116 at both dose levels are less than those of vehicle-treated mice for the duration of the study period. At 100 mg/kg po q.d., the reduction in growth is statistically significant on days 6 and 9 | ||||||||||||||||||||
| 参考文献： | 1. Wang S, et al. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53(11):4367-78. | ||||||||||||||||||||
| 溶解性： | DMSO : 15 mg/mL (40.71 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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