| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80903-1mg买3赠1 |
99.10% | ￥232.00 |
7 | - | - | - | - |
|
S80903-5mg买3赠1 |
99.10% | ￥400.00 |
7 | - | - | - | - |
|
S80903-10mg买3赠1 |
99.10% | ￥720.00 |
9 | - | - | - | - |
|
S80903-25mg买3赠1 |
99.10% | ￥750.00 |
9 | - | - | - | - |
|
S80903-50mg买3赠1 |
99.10% | ￥1200.00 |
6 | - | - | - | - |
|
S80903-100mg买3赠1 |
99.10% | ￥1900.00 |
3 | - | - | - | - |
|
| 产品描述： | SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6. | ||||||||||||||||||||
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| 靶点： | IC50: 129 nM (ALK4), 47 nM (ALK5);ALK;TGF-beta/Smad | ||||||||||||||||||||
| 体内研究： | SB-505124 (5 mg/kg; i.p.) alone has no effect in C57Bl6 mice with A549 xenografts, but administration of SB-505124 with a single dose of Carboplatin (60 mg/kg) results in durable responses without the need for maintenance therapy in five animals | ||||||||||||||||||||
| 参考文献： | 1. DaCosta Byfield S, et al. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2004 Mar;65(3):744-52. 2. Sutariya V, et al. Thermoreversible gel for delivery of receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery. Pharm Dev Technol. 2013 Jul-Aug;18(4):957-62. 3. Sapitro J, et al. Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by receptor-like kinase 5 inhibitor. Mol Vis. 2010 Sep 16;16:1880-92. 4. Marini KD, et al. Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Sci Transl Med. 2018 Jul 25;10(451). pii: eaat3504. | ||||||||||||||||||||
| 溶解性： | DMSO : 113.33 mg/mL (337.90 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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