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PF-562271

    
96.40%

PF-562271

源叶(MedMol)
S80911 一键复制产品信息
717907-75-0
C21H20F3N7O3S
507.49
PF 562271;N-甲基-N-[3-[[[2-[(2-氧代-2,3-二氢-1H-吲哚-5-基)氨基]-5-三氟甲基嘧啶-4-基]氨基]甲基]吡啶-2-基]甲磺酰胺
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S80911-5mg买3赠1
96.40%

¥476.00

6 - - - -
S80911-10mg买3赠1
96.40%

¥816.00

8 - - - -
S80911-25mg促销
96.40%

¥1490.00 ¥1190.00

3 - - - -
S80911-100mg促销
96.40%

¥3460.00 ¥2760.00

4 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively
靶点: IC50: 1.5 nM (FAK), 13 nM (Pyk2), 30 nM (CDK2), 47 nM (CDK3), 58 nM (CDK1), 97 nM (CDK7), 97 nM (Flt3);FAK;PYK2;CDK
体内研究: PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (calculated EC50 of 93 ng/mL, total) after p.o. administration to tumor-bearing mice. Rats that receive PF-562271 demonstrate a decrease in tumor growth after 2 weeks of treatment with signs of bone healing as evidenced by the deposition of new bone (cortical and cancellous) at sites previously damaged by the tumor
参考文献: 1. Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944. 2. Crompton BD, et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 1;73(9):2873-83. 3. Bagi CM, et al. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. Cancer. 2008 May 15;112(10):2313-21.
溶解性: DMSO  :  125  mg/mL  (246.31  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.97 ml 9.852 ml 19.705 ml
5 mM 0.394 ml 1.97 ml 3.941 ml
10 mM 0.197 ml 0.985 ml 1.97 ml
50 mM 0.039 ml 0.197 ml 0.394 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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