货号	规格	价格	上海	北京	珠海	重庆	武汉
S80911-5mg买3赠1	96.40%	￥476.00 S80911-5mg ￥476.00 现货（买3赠1）	6 6	-	-	-	-
S80911-10mg买3赠1	96.40%	￥816.00 S80911-10mg ￥816.00 现货（买3赠1）	8 8	-	-	-	-
S80911-25mg促销	96.40%	￥1490.00 ￥1190.00 S80911-25mg ￥1190.00 现货	3 3	-	-	-	-
S80911-100mg促销	96.40%	￥3460.00 ￥2760.00 S80911-100mg ￥2760.00 现货	4 4	-	-	-	-

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产品描述：

PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively

靶点：

IC50: 1.5 nM (FAK), 13 nM (Pyk2), 30 nM (CDK2), 47 nM (CDK3), 58 nM (CDK1), 97 nM (CDK7), 97 nM (Flt3);FAK;PYK2;CDK

体内研究：

PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (calculated EC50 of 93 ng/mL, total) after p.o. administration to tumor-bearing mice. Rats that receive PF-562271 demonstrate a decrease in tumor growth after 2 weeks of treatment with signs of bone healing as evidenced by the deposition of new bone (cortical and cancellous) at sites previously damaged by the tumor

参考文献：

1. Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944. 2. Crompton BD, et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 1;73(9):2873-83. 3. Bagi CM, et al. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. Cancer. 2008 May 15;112(10):2313-21.

溶解性：

DMSO : 125 mg/mL (246.31 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.97 ml	9.852 ml	19.705 ml
5 mM	0.394 ml	1.97 ml	3.941 ml
10 mM	0.197 ml	0.985 ml	1.97 ml
50 mM	0.039 ml	0.197 ml	0.394 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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