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OSI-930

    
99.40%

OSI-930

源叶(MedMol)
S80919 一键复制产品信息
728033-96-3
C22H16F3N3O2S
443.45
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S80919-2mg买3赠1
99.40%

¥200.00

5 - - - -
S80919-5mg买3赠1
99.40%

¥290.00

5 - - - -
S80919-10mg买3赠1
99.40%

¥510.00

6 - - - -
S80919-25mg促销
99.40%

¥660.00 ¥528.00

5 - - - -
S80919-50mg促销
≥99%

¥1110.00 ¥888.00

货期:2-3天 - - - -
S80919-100mg促销
≥99%

¥1780.00 ¥1420.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: OSI-930 is an orally selective inhibitor of Kit, KDR and CSF-1R (c-Fms) with IC50s of 80 nM, 9 nM and 15 nM, respectively. OSI-930 also moderately inhibits Flt-1, c-Raf, Lck and low activity against PDGFRα/β, Flt-3 and Abl. OSI-930 has antitumor activity
靶点: KDR:9 nM (IC50);Flt-1:8 nM (IC50);Kit:80 nM (IC50);PDGFRβ:6900 nM (IC50);PDGFRα:3408 nM (IC50);CSF-1R:15 nM (IC50);c-Raf:41 nM (IC50);Flt-3:1303 nM (IC50);Lck:22 nM (IC50);Abl:4738 nM (IC50);Apoptosis;c-Fms;Raf;VEGFR;FLT;CSF-1R;Src;c-Kit
体内研究: OSI-930 (oral gavage; once a day; 38 days; 200 mg/kg) exhibits potent antitumor activity in a broad range of preclinical xenograft models
参考文献: 1. Garton AJ, et al. OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models. Cancer Res. 2006, 66(2):1015-1024. 2. Lin HL, et al. Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug. Drug Metab Dispos. 2011, 39(2), 345-350.
溶解性: DMSO  :  50  mg/mL  (112.75  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.255 ml 11.275 ml 22.55 ml
5 mM 0.451 ml 2.255 ml 4.51 ml
10 mM 0.226 ml 1.128 ml 2.255 ml
50 mM 0.045 ml 0.226 ml 0.451 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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