货号	规格	价格	上海	北京	珠海	重庆	武汉
S80948-5mg买3赠1	99.90%	￥330.00 S80948-5mg ￥330.00 现货（买3赠1）	4 4	-	-	-	-
S80948-25mg	99.90%	￥1010.00 S80948-25mg ￥1010.00 现货	8 8	-	-	-	-
S80948-50mg	99.90%	￥1910.00 S80948-50mg ￥1910.00 现货	5 5	-	-	-	-

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产品描述：

Dinaciclib (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively

靶点：

CDK2:1 nM (IC50);CDK5:1 nM (IC50);CDK1:3 nM (IC50);CDK9:4 nM (IC50);Apoptosis;CDK

体内研究：

Dinaciclib (8, 16, 32, and 48 mg/kg, i.p.) results in tumor inhibition by 70%, 70%, 89%, and 96%, respectively; Dinaciclib (SCH 727965) is well tolerated, and the maximum body weight loss in the highest dosage group is 5%. Dinaciclib has a short plasma half-life in mouse. A dose of 5 mg/kg Dinaciclib given i.p. in mice is associated with a plasma half-life of ~0.25 hour. Treatment with Dinaciclib (SCH727965) given as twice weekly i.p. doses of 40 mg/kg for 4 weeks causes significant tumor growth inhibition (TGI) in 10/10 (100%) of low-passage subcutaneous pancreatic xenografts tested

参考文献：

1. Parry D, et al. Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol Cancer Ther. 2010 Aug;9(8):2344-53. 2. Feldmann G, et al. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther. 2011 Oct 1;12(7):598-609.

溶解性：

DMSO : 50 mg/mL (126.11 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.522 ml	12.611 ml	25.221 ml
5 mM	0.504 ml	2.522 ml	5.044 ml
10 mM	0.252 ml	1.261 ml	2.522 ml
50 mM	0.05 ml	0.252 ml	0.504 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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