货号	规格	价格	上海	北京	珠海	重庆	武汉
S80971-1mg买3赠1	99.50%	￥182.00 S80971-1mg ￥182.00 现货（买3赠1）	8 8	-	-	-	-
S80971-2mg买3赠1	99.50%	￥326.00 S80971-2mg ￥326.00 现货（买3赠1）	9 9	-	-	-	-
S80971-5mg买3赠1	99.50%	￥408.00 S80971-5mg ￥408.00 现货（买3赠1）	7 7	-	-	-	-
S80971-10mg买3赠1	99.50%	￥646.00 S80971-10mg ￥646.00 现货（买3赠1）	4 4	-	-	-	-
S80971-25mg买3赠1	99.50%	￥1420.00 S80971-25mg ￥1420.00 现货（买3赠1）	4 4	-	-	-	-
S80971-50mg买3赠1	≥99%	￥2170.00 S80971-50mg ￥2170.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S80971-100mg买3赠1	99.50%	￥3260.00 S80971-100mg ￥3260.00 现货（买3赠1）	7 7	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer

靶点：

IC50: 4 μM (LNCaP cells), 1.7 μM (Granta cells);Apoptosis;p53

体外研究：

NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation. NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells. NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin. NSC348884 (1-5 μM; 24 h) induces cell apoptosis. NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53. Cell Viability Assay Cell Line: LNCaP and Granta cell lines Concentration: 0.01-100 μM Incubation Time: 4 days Result: Inhibited LNCaP cells and Granta cell lines with IC50s of 4 and 1.7 μM, respectively. Apoptosis Analysis Cell Line: LNCaP cell line Concentration: 1-5 μM Incubation Time: 24 h Result: Induced apoptosis in LNCaP cell line. Western Blot Analysis Cell Line: LNCaP cell line Concentration: 0-5 μM Incubation Time: 0-24 h Result: Dose-dependently increased both p53 protein level and phosphorylation on Ser15, and increased the concentration of p21. Western Blot Analysis Cell Line: SKOV3, ES2 and MOSEC/Luc cell lines Concentration: 0, 2.5 and 5 μM Incubation Time: 48 h Result: Increased PD-L1 expression in ovarian cancer cells.

体内研究：

NSC348884 (50 μg; i.p. once) reduces tumor growth. Animal Model: C57Bl/6J mice with MOSEC/Luc cells injection Dosage: 50 μg Administration: Intraperitoneal injection; 50 μg once Result: Reduced tumorigenesis, but not completely inhibited.

参考文献：

1. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20. 2. Lin Y, et al. Inhibition of nucleophosmin/B23 sensitizes ovarian cancer cells to antiprogrammed cell death protein-1 ligand therapy. 2022.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.57 ml	7.852 ml	15.704 ml
5 mM	0.314 ml	1.57 ml	3.141 ml
10 mM	0.157 ml	0.785 ml	1.57 ml
50 mM	0.031 ml	0.157 ml	0.314 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置