货号	规格	价格	上海	北京	珠海	重庆	武汉
S80976-5mg买3赠1	99.39%	￥374.00 S80976-5mg ￥374.00 现货（买3赠1）	3 2 3	2	-	-	-
S80976-10mg买3赠1	99.39%	￥602.00 S80976-10mg ￥602.00 现货（买3赠1）	5 5	-	-	-	-
S80976-25mg	99.39%	￥960.00 S80976-25mg ￥960.00 现货	3 3	-	-	-	-
S80976-50mg	≥98%	￥1530.00 S80976-50mg ￥1530.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig

靶点：

CPT-1a;Apoptosis

体内研究：

Etomoxir significantly inhibits the decrease of bone mineral density (BMD) and bone breaking strength in db/db and high fat (HF)-fed mice and suppresses the reduction of BMSCs-differentiated osteoblasts. Etomoxir inhibits the increase of mitochondrial ROS generation in db/db and HF-fed mice and osteoblasts. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.

参考文献：

1. Roddy S O'Connor, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.Sci Rep. 2018 Apr 19;8(1):6289. 2. Fred Y Xu,et al.Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells.J Lipid Res. 2003 Feb;44(2):415-23. 3. Jun Li, et al. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus.Sci Rep. 2015 Jul 31;5:12724. 4. Joost J F P Luiken, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.Biochem J. 2009 Apr 15;419(2):447-55.

溶解性：

DMSO : 50 mg/mL (155.89 mM; Need ultrasonic) H2O : 5 mg/mL (15.59 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.118 ml	15.588 ml	31.177 ml
5 mM	0.624 ml	3.118 ml	6.235 ml
10 mM	0.312 ml	1.559 ml	3.118 ml
50 mM	0.062 ml	0.312 ml	0.624 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ANTI-EAPII (TTRAP)

(R)-Etomoxir sodium salt

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)