货号	规格	价格	上海	北京	珠海	重庆	武汉
S80982-1mg买3赠1	98.90%	￥100.00 S80982-1mg ￥100.00 现货（买3赠1）	7 7	-	-	-	-
S80982-5mg买3赠1	98.90%	￥178.00 S80982-5mg ￥178.00 现货（买3赠1）	5 5	-	-	-	-
S80982-25mg买3赠1	98.90%	￥530.00 S80982-25mg ￥530.00 现货（买3赠1）	6 6	-	-	-	-
S80982-100mg买3赠1	98.90%	￥1340.00 S80982-100mg ￥1340.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)

靶点：

Ki: 30 nM (Syk) IC50: 41 nM (Syk) FLT3 IC50: 63 nM (Lyn), 37 nM (Lck);Apoptosis;FLT;Syk

体内研究：

R406 (5 and 10 mg/kg) shows efficacy in the amelioration of the Arthus reaction and in reducing clinical symptoms in the collagen antibody-induced arthritis (CAIA) and K/BxN models of rheumatoid arthritis (RA). Immune complex (IC)-mediated inflammation is reduced by inhibition of Fc receptor signaling with R406

参考文献：

1. Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. 2. Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8.

溶解性：

DMSO : ≥ 61 mg/mL (97.04 mM) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.591 ml	7.954 ml	15.908 ml
5 mM	0.318 ml	1.591 ml	3.182 ml
10 mM	0.159 ml	0.795 ml	1.591 ml
50 mM	0.032 ml	0.159 ml	0.318 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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