货号	规格	价格	上海	北京	珠海	重庆	武汉
S80994-5mg买3赠1	99.79%	￥172.00 S80994-5mg ￥172.00 现货（买3赠1）	8 8	-	-	-	-
S80994-25mg买3赠1	99.79%	￥300.00 S80994-25mg ￥300.00 现货（买3赠1）	9 9	-	-	-	-
S80994-100mg买3赠1	99.79%	￥760.00 S80994-100mg ￥760.00 现货（买3赠1）	10 10	-	-	-	-
S80994-500mg买3赠1	99.79%	￥1800.00 S80994-500mg ￥1800.00 现货（买3赠1）	5 5	-	-	-	-
S80994-1g买3赠1	99.79%	￥2800.00 S80994-1g ￥2800.00 现货（买3赠1）	2 2	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis

靶点：

VEGFR2:0.035 nM (IC50);Flt-4:6 nM (IC50);Flt-1:12 nM (IC50);VEGFR;FLT;c-Met/HGFR;TAMReceptor;c-Kit;ROR

体内研究：

Cabozantinib (100 mg/kg, Orally, once) inhibits MET and VEGFR2 phosphorylation in mice. Cabozantinib (100 mg/kg, Orally, once) significantly increases tumor hypoxia and apoptosis. Cabozantinib (0-60 mg/kg, Orally, once daily for 14 days) inhibits tumor growth in a dose-dependent manner.

参考文献：

1. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308. 2. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768. 3. Fuse MA, et al. Combination Therapy With c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells. Mol Cancer Ther. Mol Cancer Ther. 2017 Nov;16(11):2387-2398.

溶解性：

DMSO : 25 mg/mL (49.85 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.994 ml	9.97 ml	19.939 ml
5 mM	0.399 ml	1.994 ml	3.988 ml
10 mM	0.199 ml	0.997 ml	1.994 ml
50 mM	0.04 ml	0.199 ml	0.399 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Cabozantinib (XL184, BMS-907351)