货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S81003-5mg买3赠1	98.24%	￥800.00 S81003-5mg ￥800.00 现货（买3赠1）	5 5	-	-	-	-
S81003-25mg买3赠1	≥98%	￥2400.00 S81003-25mg ￥2400.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S81003-5mg买3赠1

98.24%

￥800.00

S81003-25mg买3赠1

≥98%

￥2400.00

货期：2-3天

产品名称:

linaclotide

规格或纯度:

Moligand™

作用类型:

激动剂

作用机制:

热稳定肠毒素受体激动剂

靶点：

Guanylate Cyclase;Guanylatecyclase

体内研究：

Pharmacokinetic analysis shows very low oral bioavailability (0.10%). In intestinal secretion and transit models, linaclotide exhibits significant pharmacological effects in wt, but not in GC-C null mice: induction of increased fluid secretion into surgically ligated jejunal loops is accompanied by the secretion of elevated levels of cyclic guanosine-3',5-monophosphate and accelerated gastrointestinal transit. Linaclotide significantly increases weekly spontaneous bowel movements and complete spontaneous bowel movements (CSBMs) while reducing abdominal pain in patients with chronic constipation

参考文献：

1. Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19-20):760-5. 2. Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91.

溶解性：

DMSO : 50 mg/mL (32.75 mM; Need ultrasonic) H2O : 16.67 mg/mL (10.92 mM; ultrasonic and adjust pH to 2 with HCl)

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.655 ml	3.275 ml	6.55 ml
5 mM	0.131 ml	0.655 ml	1.31 ml
10 mM	0.065 ml	0.327 ml	0.655 ml
50 mM	0.013 ml	0.065 ml	0.131 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=1.61] Xin-Yi Liu et al."Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH.

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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