货号	规格	价格	上海	北京	珠海	重庆	武汉
S81008-5mg买3赠1	99.70%	￥480.00 S81008-5mg ￥480.00 现货（买3赠1）	9 9	-	-	-	-
S81008-10mg买3赠1	99.70%	￥600.00 S81008-10mg ￥600.00 现货（买3赠1）	9 9	-	-	-	-
S81008-50mg买3赠1	99.70%	￥1200.00 S81008-50mg ￥1200.00 现货（买3赠1）	2 2	-	-	-	-
S81008-100mg买3赠1	99.70%	￥2000.00 S81008-100mg ￥2000.00 现货（买3赠1）	2 2	-	-	-	-

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产品描述：

ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research

靶点：

Bcl-2:30.3 nM (EC50);Bcl-xL:78.7 nM (EC50);Bcl-W:197.8 nM (EC50);Bcl-B:1820 nM (EC50);Bfl-1:>10 μM (EC50);Mcl-1:>10 μM (EC50);Mitophagy; BCL; Autophagy

体内研究：

ABT-737 (20, 30 mg/kg/day; i.p.; for 21 days) suppresses the leukemia burden by 48% and 53% at the 20 and 30 mg/kg dose levels, respectively, in four- to six-week-old CB.17 Scid mice with human leukemia KG-1 cells. ABT-737 significantly extends survival of mice in this aggressive leukemia model.

参考文献：

1. Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88. 2. Ahamed Saleem, et al. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate. 2012 Sep 1;72(12):1374-81. 3. Clerc P, et al. Polster BM.Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry.PLoS One. 2012;7(8):e42487. Epub 2012 Aug 3.

溶解性：

DMSO : 50 mg/mL (61.47 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.229 ml	6.147 ml	12.294 ml
5 mM	0.246 ml	1.229 ml	2.459 ml
10 mM	0.123 ml	0.615 ml	1.229 ml
50 mM	0.025 ml	0.123 ml	0.246 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=6.9] Xiaoxue Lang et al."TPGS nanoparticles co-loaded with ABT-737 and R848 for breast cancer therapy."BIOMEDICINE & PHARMACOTHERAPY.2024 Aug;177:117107

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