| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81012-5mg促销 |
≥99% | ￥360.00 ￥324.00 |
10 | - | - | - | - |
|
S81012-10mg促销 |
≥99% | ￥582.00 ￥522.00 |
6 | - | - | - | - |
|
S81012-25mg促销 |
≥99% | ￥998.00 ￥898.00 |
2 | - | - | - | - |
|
S81012-50mg促销 |
≥99% | ￥1510.00 ￥1350.00 |
货期：3-5天 | - | - | - | - |
|
S81012-100mg促销 |
≥99% | ￥2310.00 ￥2070.00 |
2 | - | - | - | - |
|
| 产品描述： | (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells | ||||||||||||||||||||
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| 靶点： | PDE4:1100 nM (IC50);Apoptosis; PDE | ||||||||||||||||||||
| 体内研究： | (+)-Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats. (+)-Rolipram (0.06-25 mg/kg; a single i.p.) causes a dose-related fall in rectal temperature of rats | ||||||||||||||||||||
| 参考文献： | 1. Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13. 2. Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4. 3. Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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