货号	规格	价格	上海	北京	珠海	重庆	武汉
S81047-5mg促销	≥98%	￥568.00 ￥510.00 S81047-5mg ￥510.00 现货	10 10	-	-	-	-
S81047-10mg促销	≥98%	￥908.00 ￥816.00 S81047-10mg ￥816.00 现货	10 10	-	-	-	-
S81047-25mg促销	≥98%	￥1250.00 ￥1120.00 S81047-25mg ￥1120.00 现货	7 7	-	-	-	-
S81047-50mg促销	≥98%	￥2000.00 ￥1800.00 S81047-50mg ￥1800.00 现货	6 6	-	-	-	-
S81047-100mg促销	≥98%	￥3210.00 ￥2880.00 S81047-100mg ￥2880.00 现货	4 4	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.

靶点：

Ki: 28 nM (XIAP BIR3), 14 nM (MLIAP-BIR3), 17 nM (cIAP1-BIR3), 43 nM (cIAP2-BIR3);IAP

体内研究：

GDC-0152 has moderate predicted hepatic clearance based on metabolic stability assays conducted using human liver microsomes. Plasma−protein binding of GDC-0152 is moderate and comparable among mice (88−91%), rats (89−91%), dogs (81−90%), monkeys (76−85%), and humans (75−83%) over the range of concentrations investigated (0.1−100 μM); higher plasma−protein binding is observed in rabbits (95−96%). GDC-0152 does not preferentially distribute to red blood cells with blood−plasma partition ratios ranging from 0.6 to 1.1 in all species tested. The pharmacokinetics for GDC-0152 is achieved with a C max of 53.7 μM and AUC of 203.5 h·μM

参考文献：

1. Flygare JA, et al. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.005 ml	10.027 ml	20.055 ml
5 mM	0.401 ml	2.005 ml	4.011 ml
10 mM	0.201 ml	1.003 ml	2.005 ml
50 mM	0.04 ml	0.201 ml	0.401 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置