| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81050-1mg买3赠1 |
98.10% | ￥340.00 |
2 | 2 | - | - | - |
|
S81050-5mg促销 |
98.10% | ￥900.00 ￥675.00 |
5 | - | - | - | - |
|
S81050-10mg促销 |
98.10% | ￥1350.00 ￥1012.00 |
5 | - | - | - | - |
|
S81050-25mg促销 |
98.10% | ￥2320.00 ￥1740.00 |
6 | - | - | - | - |
|
S81050-50mg促销 |
98.10% | ￥3220.00 ￥2415.00 |
5 | - | - | - | - |
|
S81050-100mg促销 |
≥98% | ￥5390.00 ￥4042.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity. Quisinostat can induce autophagy in neuroblastoma cells |
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| 靶点： | HDAC1:0.11 nM (IC50);HDAC2:0.33 nM (IC50);HDAC4:0.64 nM (IC50);HDAC10:0.46 nM (IC50);HDAC11:0.37 nM (IC50);HDAC3:4.86 nM (IC50);HDAC5:3.69 nM (IC50);HDAC8:4.26 nM (IC50);HDAC9:32.1 nM (IC50);HDAC6:76.8 nM (IC50);HDAC7:119 nM (IC50);Apoptosis; HDAC; Autophagy | ||||||||||||||||||||
| 体内研究： | Quisinostat (40 mg/kg; p.o.; once daily; for 3 days) acts as a potent HDAC1 inhibitor p21waf1,cip1 ZsGreen tumors in vivo. Quisinostat induces continuous H3 acetylation in tumor tissue in vivo. Quisinostat (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts | ||||||||||||||||||||
| 参考文献： | 1. Arts J, et al. JNJ-26481585, a novel second-generation oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res. 2009 Nov 15;15(22):6841-51. 2. Vamsi Krishna Kommalapati, et al. Inhibition of JNJ-26481585-mediated autophagy induces apoptosis via ROS activation and mitochondrial membrane potential disruption in neuroblastoma cells. Mol Cell Biochem. 2020 May;468(1-2):21-34. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京