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Trandolapril

    
98.70%

Trandolapril

源叶(MedMol)
S81053 一键复制产品信息
87679-37-6
C24H34N2O5
430.54
群多普利
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S81053-5mg促销
98.70%

¥309.00 ¥300.00

6 - - - -
S81053-25mg促销
98.70%

¥964.00 ¥960.00

5 - - - -
S81053-100mg促销
98.70%

¥2680.00 ¥2410.00

3 - - - -
S81053-250mg促销
98.70%

¥4630.00 ¥4170.00

2 - - - -
S81053-500mg促销
≥98%

¥6480.00 ¥5830.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述:

Trandolapril (RU44570) is a nonsulfhydryl prodrug that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI)

靶点: Target: Angiotensin-converting Enzyme (ACE);Angiotensin-convertingEnzyme(ACE)
体内研究: Trandolapril (3 mg/kg/day; p.o.; 7 d) reduces renal fibrosis in obstructive nephropathy in mice, by inhibiting renal interstitial matrix expression and myofibroblast activation, decreasing renal proinflammatory cytokine RANTES and TNF-α level. Trandolapril (0.3 mg/kg/day; p.o.; 4 weeks) improves arterial mechanics in rats, prevents arterial hypertrophy, collagen and cellular fibronectin accumulation. randolapril (0.3 mg/kg/day; p.o.; 4 months) exhibits a chronic anti-hypertension effects in rats, results in blood pressure decreasing. Trandolapril (0.25 mg/kg; p.o.; twice a day; 4 months) inhibits Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit
参考文献: 1. Peters DC, et al. Trandolapril. An update of its pharmacology and therapeutic use in cardiovascular disorders. Drugs. 1998 Nov;56(5):871-93. 2. Tan X, et al. Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. Kidney Int. 2009 Dec;76(12):1248-57. 3. Koffi I, et al. Prevention of arterial structural alterations with verapamil and trandolapril and consequences for mechanical properties in spontaneously hypertensive rats. Eur J Pharmacol. 1998 Nov 13;361(1):51-60. 4. Chobanian AV, et al. Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Hypertension. 1992 Oct;20(4):473-7.
溶解性: Soluble  in  DMSO
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.323 ml 11.613 ml 23.227 ml
5 mM 0.465 ml 2.323 ml 4.645 ml
10 mM 0.232 ml 1.161 ml 2.323 ml
50 mM 0.046 ml 0.232 ml 0.465 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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