货号	规格	价格	上海	北京	武汉	南京	购买数量
S81068-10mg	98%	￥500.00 S81068-10mg ￥500.00 现货	12 >10	-	-	-
S81068-100mg	98%	￥1900.00 S81068-100mg ￥1900.00 现货	9 9	-	-	-

产品介绍

Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized

产品描述：

Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized

靶点：

Calcium Channel;CalciumChannel

体内研究：

Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats.

参考文献：

1.Yoshiyama M, et al. Jpn Circ J, 1998, 62(1), 47-52. 2.Rossoni G, et al. Eur J Pharmacol, 2008, 587(1-3), 224-230. 3.Roth M, et al. Proc Natl Acad Sci U S A, 1992, 89(9), 4071-4075. 4.Tojo A, et al. J Cardiovasc Pharmacol, 1992, 20(6), 895-899. 5.Huang S, et al. Am Heart J, 1993, 125(2 Pt 2), 589-597.

溶解性：

DMSO:113 mg/mL (185 mM) H2O:<1 mg/mL Ethanol:3 mg/mL (4.91 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.637 ml	8.187 ml	16.375 ml
5 mM	0.327 ml	1.637 ml	3.275 ml
10 mM	0.164 ml	0.819 ml	1.637 ml
50 mM	0.033 ml	0.164 ml	0.327 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Manidipine