货号	规格	价格	上海	北京	珠海	重庆	武汉
S81070-2mg买3赠1	99.20%	￥296.00 S81070-2mg ￥296.00 现货（买3赠1）	4 4	-	-	-	-
S81070-5mg买3赠1	99.20%	￥420.00 S81070-5mg ￥420.00 现货（买3赠1）	6 6	-	-	-	-
S81070-10mg买3赠1	99.20%	￥680.00 S81070-10mg ￥680.00 现货（买3赠1）	3 3	-	-	-	-
S81070-25mg买3赠1	99.20%	￥1360.00 S81070-25mg ￥1360.00 现货（买3赠1）	6 6	-	-	-	-
S81070-50mg买3赠1	≥99%	￥2320.00 S81070-50mg ￥2320.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S81070-100mg买3赠1	≥99%	￥3450.00 S81070-100mg ￥3450.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.

靶点：

Apoptosis;NAMPT;Apoptosis; NAMPT

体内研究：

STF-118804 (25 mg/kg twice daily, s.c.) improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and effectively depletes leukemia-initiating cells.

细胞实验：

Human cell lines or lineage negative cord blood cells were seeded into 96-well plates (6×105 cells per milliliter). Compounds are added in increasing concentrations, and cells are incubated at 37°C/5% CO2 for 72 hours. To detect viability, CellTiter-Blue reagent is added at 1:10 dilution, and plates are incubated for 4 hours at 37°C/5% CO2 prior to reading on a Flexstation II 384 or a Synergy H1 reader at an excitation of 555 nm and emission detection of 590 nm. Cell viability is also measured by CellTiter-Fluor. The cell-permeable ?uorogenic peptide substrate GF-AFC reagent is added at 1:2 dilution, and plates are incubated for 30 min at 37°C/5% CO2 prior to reading on a Synergy H1 reader at an excitation of 380 nm and emission detection of 505 nm. Cord blood cells are enumerated on a hemocytometer, and cell viability is assessed with trypan blue exclusion dye. Inhibitory concentration (IC50) is calculated using Prism software. Primary patient samples are plated in 96-well plates and treated with increasing

参考文献：

1.Matheny CJ, et al. Chem Biol. 2013, 20(11), 1352-1363.

溶解性：

DMSO:46.2 mg/mL (100 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.167 ml	10.834 ml	21.667 ml
5 mM	0.433 ml	2.167 ml	4.333 ml
10 mM	0.217 ml	1.083 ml	2.167 ml
50 mM	0.043 ml	0.217 ml	0.433 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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