货号	规格	价格	上海	北京	武汉	南京
S81083-1mg	98.9%	￥200.00 S81083-1mg ￥200.00 现货	4 4	-	-	-
S81083-2mg	98.9%	￥352.00 S81083-2mg ￥352.00 现货	5 5	-	-	-
S81083-5mg	98.9%	￥480.00 S81083-5mg ￥480.00 现货	7 7	-	-	-
S81083-10mg	≥98%	￥800.00 S81083-10mg ￥800.00 2-3天	0 货期：2-3天	-	-	-
S81083-25mg	98.9%	￥1600.00 S81083-25mg ￥1600.00 现货	3 3	-	-	-
S81083-50mg	≥98%	￥2240.00 S81083-50mg ￥2240.00 2-3天	0 货期：2-3天	-	-	-
S81083-100mg	≥98%	￥4000.00 S81083-100mg ￥4000.00 2-3天	0 货期：2-3天	-	-	-

大包装询价收藏产品

加入购物车

产品介绍

AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.

产品描述：

AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.

靶点：

CDK9/Cyclin T:10 nM (IC50);CDK5/p35:13 nM (IC50);cdk2/cyclin A:47 nM (IC50);Cdk4/cyclin D1:100 nM (IC50);cdk6/cyclin D3:170 nM (IC50);Cdk1/cyclin B:210 nM (IC50);CDK7/Cyclin H/MAT1:2400 nM (IC50);GSK3β:89 nM (IC50);Apoptosis; GSK-3; CDK

体内研究：

AT7519 inhibits tumor growth in a human MM xenograft mouse model. AT7519 (4.6 and 9.1 mg/kg/dose) inhibits the growth of early-stage HCT116 tumor xenografts. AT7519 (10 mg/kg, i.p.) also inhibits the target CDKs in HCT116 tumor-bearing BALB/c nude mice

参考文献：

1. Santo L, et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29(16):2325-36. 2. Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. 3. Squires MS, et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9(4):920-8.

溶解性：

DMSO : ≥ 300 mg/mL (716.49 mM) H2O : 8.33 mg/mL (19.89 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.388 ml	11.941 ml	23.883 ml
5 mM	0.478 ml	2.388 ml	4.777 ml
10 mM	0.239 ml	1.194 ml	2.388 ml
50 mM	0.048 ml	0.239 ml	0.478 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

AT7519 Hydrochloride

4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide Monohydrochloride