|
产品描述： Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research |
|
靶点：
Oxytocin Receptor;Vasopressin Receptor;OxytocinReceptor; VasopressinReceptor |
体内研究：
The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes. Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice. |
参考文献：
1. Sanu O, et al. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9. 2. Philip J Ryan, et al. Oxytocin-receptor-expressing Neurons in the Parabrachial Nucleus Regulate Fluid Intake. Nat Neurosci. 2017 Dec;20(12):1722-1733. |
|
溶解性：
H2O : 16.67 mg/mL (16.77 mM; Need ultrasonic) DMSO : ≥ 16.67 mg/mL (16.77 mM) |
|
保存条件：
-20℃ |
配置溶液浓度参考：
|
1mg |
5mg |
10mg |
| 1 mM |
1.006 ml |
5.029 ml |
10.058 ml |
| 5 mM |
0.201 ml |
1.006 ml |
2.012 ml |
| 10 mM |
0.101 ml |
0.503 ml |
1.006 ml |
| 50 mM |
0.02 ml |
0.101 ml |
0.201 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京