| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81092-2mg买3赠1 |
99.20% | ￥360.00 |
9 | - | - | - | - |
|
S81092-5mg买3赠1 |
99.20% | ￥600.00 |
8 | - | - | - | - |
|
S81092-10mg买3赠1 |
99.20% | ￥800.00 |
8 | - | - | - | - |
|
S81092-25mg促销 |
99.20% | ￥1440.00 ￥1150.00 |
7 | - | - | - | - |
|
S81092-50mg促销 |
99.20% | ￥2400.00 ￥1920.00 |
4 | - | - | - | - |
|
S81092-100mg促销 |
99.20% | ￥3360.00 ￥2680.00 |
5 | - | - | - | - |
|
| 产品描述： | Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties | ||||||||||||||||||||
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| 靶点： | ROCK2:105 nM (IC50);ROCK1:24 μM (IC50);ROCK | ||||||||||||||||||||
| 体内研究： | Belumosudil (KD-025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males | ||||||||||||||||||||
| 参考文献： | 1. Boerma, M., et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase. Blood Coagul Fibrinolysis. 2008 Oct;19(7):709-18. 2. Lee, J.H., et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14. | ||||||||||||||||||||
| 溶解性： | DMSO : 250 mg/mL (552.47 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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