| 产品描述： | Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties |
| 靶点： |
ROCK2:105 nM (IC50);ROCK1:24 μM (IC50);ROCK |
| 体内研究： |
Belumosudil (KD-025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males |
| 参考文献： |
1. Boerma, M., et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase. Blood Coagul Fibrinolysis. 2008 Oct;19(7):709-18. 2. Lee, J.H., et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14. |
| 溶解性： |
DMSO : 250 mg/mL (552.47 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.21 ml |
11.049 ml |
22.099 ml |
| 5 mM |
0.442 ml |
2.21 ml |
4.42 ml |
| 10 mM |
0.221 ml |
1.105 ml |
2.21 ml |
| 50 mM |
0.044 ml |
0.221 ml |
0.442 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京