货号	规格	价格	上海	北京	珠海	重庆	武汉
S81099-5mg买3赠1	99.00%	￥640.00 S81099-5mg ￥640.00 现货（买3赠1）	4 4	-	-	-	-
S81099-10mg买3赠1	99.00%	￥1150.00 S81099-10mg ￥1150.00 现货（买3赠1）	4 4	-	-	-	-
S81099-25mg买3赠1	99.00%	￥1920.00 S81099-25mg ￥1920.00 现货（买3赠1）	5 5	-	-	-	-

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产品描述：

Lexibulin (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin induces cell apoptosis and induces mitochondrial ROS generation in GC cells

靶点：

IC50 value: 10-100 nM(cell assay);Apoptosis; ReactiveOxygenSpecies; MicrotubuleAssociated

体内研究：

iIn a xenograft model using the human prostate cancer cell line PC3, oral dosing of Lexibulin (CYT-997) is initiated 13 days after cell implantation by which time palpable tumors were evident. A dose-dependent inhibition of tumor growth was apparent with Lexibulin (CYT-997), which at the highest dose was equivalent to parenterally administered paclitaxel. A single dose of Lexibulin (CYT-997) (7.5 mg/kg i.p.) clearly decreased blood flow in liver metastases, and a significant reduction in blood flow was present 6 hours postdose. Lexibulin (CYT-997) treatment (15 mg/kg/day) significantly prolongs the survival in a murine model of aggressive systemic myelomatosis

参考文献：

1. Burns CJ, et al. CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Mol Cancer Ther. 2009 Nov;8(11):3036-45. 2. Monaghan K, et al. CYT997 causes apoptosis in human multiple myeloma. Invest New Drugs. 2011 Apr;29(2):232-8. 3. Ya Cao, wt al. Mitochondrial ROS Accumulation Inhibiting JAK2/STAT3 Pathway Is a Critical Modulator of CYT997-induced Autophagy and Apoptosis in Gastric Cancer. J Exp Clin Cancer Res. 2020 Jun 23;39(1):119.

溶解性：

DMSO : ≥ 100 mg/mL (230.13 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.301 ml	11.507 ml	23.013 ml
5 mM	0.46 ml	2.301 ml	4.603 ml
10 mM	0.23 ml	1.151 ml	2.301 ml
50 mM	0.046 ml	0.23 ml	0.46 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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CYT997 (Lexibulin)