货号	规格	价格	上海	北京	珠海	重庆	武汉
S81106-5mg买3赠1	99.10%	￥105.00 S81106-5mg ￥105.00 现货（买3赠1）	6 6	-	-	-	-
S81106-25mg买3赠1	99.10%	￥360.00 S81106-25mg ￥360.00 现货（买3赠1）	3 3	-	-	-	-
S81106-50mg买3赠1	99.10%	￥520.00 S81106-50mg ￥520.00 现货（买3赠1）	6 6	-	-	-	-

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靶点：

Apoptosis;Parasite;Apoptosis; Dehydrogenase; Parasite

体内研究：

RRx-001 (5 mg/kg or 10 mg/kg, I.V., thrice-weekly for 24 days) inhibits tumor growth and prolongs survival in a xenograft mouse model. RRx-001 (10 mg/kg, IP, twice a week and once a day) exhibits potent anti-cancer activity on the A549 lung cancer model dependent on the presence of tumor-associated macrophages (TAMs) in tumor tissue.

参考文献：

1. Das DS, et al. A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells. Leukemia. 2016 Nov;30(11):2187-2197. 2. Yalcin O, et al. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria. Malar J. 2015 May 28;14:218. 3. Cabrales P, et al. RRx-001 Acts as a Dual Small Molecule Checkpoint Inhibitor by Downregulating CD47 on Cancer Cells and SIRP-α on Monocytes/Macrophages. Transl Oncol. 2019 Apr;12(4):626-632.

溶解性：

DMSO : ≥ 100 mg/mL (373.11 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.731 ml	18.655 ml	37.311 ml
5 mM	0.746 ml	3.731 ml	7.462 ml
10 mM	0.373 ml	1.866 ml	3.731 ml
50 mM	0.075 ml	0.373 ml	0.746 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=17.1] Yurong Wei et al."Quantitatively Lighting up the Spatial Organization of CD47/SIRPα Immune Checkpoints on the Cellular Membrane with Single-Molecule Localization Microscopy."ACS Nano.2023;XXXX(XXX):XXX-XXX

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

RRX-001