货号	规格	价格	上海	北京	珠海	重庆	武汉
S81111-5mg买3赠1	99.80%	￥42.00 S81111-5mg ￥42.00 现货（买3赠1）	19806 >10	-	-	-	-
S81111-10mg买3赠1	99.80%	￥68.00 S81111-10mg ￥68.00 现货（买3赠1）	9906 >10	-	-	-	-
S81111-50mg买3赠1	99.80%	￥272.00 S81111-50mg ￥272.00 现货（买3赠1）	1986 >10	-	-	-	-
S81111-100mg买3赠1	99.80%	￥320.00 S81111-100mg ￥320.00 现货（买3赠1）	995 >10	-	-	-	-
S81111-500mg买3赠1	≥99%	￥830.00 S81111-500mg ￥830.00 现货（买3赠1）	198 >10	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively

靶点：

IC50: 2/3.7/4.4 nM (mSGLT2/rSGLT2/hSGLT2, in CHOK cells);SGLT

体外研究：

Canagliflozin inhibits Na+-dependent 14C-AMG uptake in CHO-hSGLT2 cells, with an IC50 of 4.4±1.2 nM. Similar IC50 values are obtained in CHO-rSGLT2 and CHO-mSGLT2 cells (IC50 = 3.7 and 2.0 nM for rat and mouse SGLT2, respectively). Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 684±159 nM and >1,000 nM, respectively

体内研究：

Canagliflozin (30 mg/kg treatment for 4 weeks) reduced blood glucose (BG) levels, respiratory exchange ratio, and body weight gain in DIO mice. Canagliflozin (3 mg/kg for 3 weeks) increases urinary glucose excretion (UGE) with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight In ZF rats. Animal Model: Diet-induced obese, insulin resistantmice (DIO) Mice Dosage: 30 mg/kg Administration: Oral gavage; daily; 4 weeks Result: Reduced BG levels, respiratory exchange ratio, and body weight gain. Animal Model: Male Zucker fatty (ZF) obese, insulin resistant rats Dosage: 3 mg/kg Administration: Oral gavage; daily; 3 weeks Result: UGE was increased with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight.

参考文献：

1. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.205 ml	11.025 ml	22.05 ml
5 mM	0.441 ml	2.205 ml	4.41 ml
10 mM	0.22 ml	1.102 ml	2.205 ml
50 mM	0.044 ml	0.22 ml	0.441 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Canagliflozin (hemihydrate)